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+The exception to the rule is the DOT1 household, members of which methylate K79 within the globular area of histone H3 and that are structurally not related to SET-area proteins four - 6 Recent work means that SET-area-containing proteins methylate a number of proteins along with histones (see later); they should therefore be named protein lysine methyltransferases somewhat than histone lysine methyltransferases. These tails are topic to a number of put up-translational covalent modifications, including acetylation, phosphorylation, ubiquitination, sumoylation and methylation (reviewed in 1 ). Methylation been found on a variety of lysine residues in varied histones: K4 (utilizing the one-letter amino-acid code for lysine), K9, K27, K36 and K79 in histone H3, K20 in histone H4, K59 within the globular area of histone H4 2 and K26 of histone H1B three A number of proteins responsible for the methylation of specific residues have been characterised, and all however one in all these contains a SET area; they make up the SET-area protein methyltransferase family (Table 1 ).
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